結論

 據我們所知，這是第一個全面的研究，清楚地顯示了類藥物化合物的內在表面性質對生物相關介質中溶解度增強的影響，而不是在水介質中。這項研究表明，臨界膠束濃度（描述化合物在膠束中自締合的內在能力）比公認的親脂性更好地預測FaSSIF中的溶解度增強。我們的研究表明，考慮到化合物在膠束中結合的趨勢，藥物優化策略將潛在地受益，作為增加腸道吸收的一種方式。

作者信息

通訊作者

 *電話：+41616881941。傳真：+41616882908。電子郵件：魯本。阿爾瓦雷斯_ sanchez roche.com.

筆記

作者聲明沒有相互競爭的經濟利益。

致謝

 作者要感謝比約恩·瓦格納、維吉尼·米卡列夫、伊莎貝爾·帕里拉和薩賓·皮塔提供的技術援助，以及弗蘭茲·舒勒、薩拉·貝利和喬恩·凱爾·博德納爾對手稿的修訂和寶貴意見。

縮寫

 FaSSIF，禁食狀態模擬腸液；FeSSIF，喂食狀態模擬腸液；臨界膠束濃度；生物制藥分類系統；SE，溶解度增強；logd，辛醇/水分配系數；電離常數

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